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  • Immunomodulatory effect of sulfated galactofucan from marine macroalga Turbinaria conoides

    Sulfated polysaccharides are effective immunostimulating agents by activating several intracellular signaling pathways. A sulfated (1 ? 3)/(1 ? 4)-linked galactofucan TCP-3 with promising immunomodulatory effects was purified from a marine macroalga Turbinaria conoides. The immune-enhancing potential of TCP-3 (100–400 mg/kg BW) was evaluated on cyclophosphamide-induced immunosuppressed animals by increasing bone marrow cellularity (10–13 cells/femur/mL x 106), ?-esterase activity (1200–1700 number of positive cells/4000 BMC), interferon-? (1.31–1.49 pg/mL), interleukin-2 (3.49–3.99 pg/mL) secretion, and WBC count (> 3000 cells/cu mm). The proliferation of lymphocytes for in vitro and in vivo conditions was enhanced by administering TCP-3 besides regulating the secretion of pro-inflammatory cytokines (interleukin-6/1?/12, tumor necrosis factor-?, transforming growth factor-?), and an inducible isoform of nitric oxide synthase.

     

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